# Bionanointerfaces ## expand\_more #### Bionanointerfaces Cells of all types take cues from the surfaces they encounter in their environment. The cells extract any or all of the mechanical, chemical, spatial, and even temporal information from the surface, but which features they read and how they integrate and translate them into specific behavioral responses is still almost a black box. ## Projects [### Flagella-surface interactions ](/flagella-surface-interactions) ![flagella_project.jpg](/sites/g/files/omnuum6296/files/styles/hwp_16_9__480x270/public/aizenberg/files/flagella_project.jpg?itok=jQZrOUUK) [### Vascularized self-lubricating surfaces ](/vascularized-self-lubricating-surfaces-0) ![figure_5_-_1.jpg](/sites/g/files/omnuum6296/files/styles/hwp_16_9__480x270/public/aizenberg/files/figure_5_-_1.jpg?itok=Y81ENdYC) [### Bacterial communities on periodic nanostructures ](/bacterial-communities-periodic-nanostructures) ![e_coli_flagella.jpg](/sites/g/files/omnuum6296/files/styles/hwp_16_9__480x270/public/aizenberg/files/e_coli_flagella.jpg?itok=gnEkmSx2) [### Stem cell development on nanopillars ](/stem-cell-development-nanopillars) ![stem_cell_on_nanopillar_array.jpg](/sites/g/files/omnuum6296/files/styles/hwp_16_9__480x270/public/aizenberg/files/stem_cell_on_nanopillar_array.jpg?itok=7idOXMNg) [### Marine larval settlement ](/marine-larval-settlement) ![urchin.surface.jpg](/sites/g/files/omnuum6296/files/styles/hwp_16_9__480x270/public/aizenberg/files/urchin.surface.jpg?itok=64vzJ0iT) Publications In the News ## Publications Download 26 citations download- [BibTeX](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=tagged) - [Marc](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=marc) - [PubMedId](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=standard_pager&number_of_items=15&sort_field=bibcite_year--desc&taxonomy_filters%5Bfield_hwp_c_affiliated_authors%5D&taxonomy_filters%5Bfield_hwp_c_project%5D&taxonomy_filters%5Bfield_hwp_c_publicationgroupaffi%5D&taxonomy_filters%5Bfield_hwp_c_researchtopics12%5D%5B0%5D%5Btarget_id%5D=106116&taxonomy_filters%5Bfield_hwp_c_year123456%5D&&&format=ris) ### 2025 Karimi Z, Flores I, Kolle S, Kundu S, Walton E, Badder L, Levy N, Berry DB, Schar D, Levy J, et al. [Mitigating Algal Competition with Fouling-Prevention Coatings for Coral Restoration and Reef Engineering](/publication/mitigating-algal-competition-fouling-prevention-coatings-coral-restoration-and-reef). ACS Sustainable Chemistry & Engineering. 2025;13:5808–5817. Karimi Z, Flores I, Kolle S, Kundu S, Walton E, Badder L, Levy N, Berry DB, Schar D, Levy J, et al. [Mitigating Algal Competition with Fouling-Prevention Coatings for Coral Restoration and Reef Engineering](/publication/mitigating-algal-competition-fouling-prevention-coatings-coral-restoration-and-reef). ACS Sustainable Chemistry & Engineering. 2025;13:5808–5817. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1021/acssuschemeng.4c07508) Coral reefs are undergoing unprecedented degradation due to rising ocean temperatures, acidification, overfishing, and coastal pollution. Despite conservation efforts, including marine protected areas and sustainable fishing practices, the magnitude of... - [ descriptionPublisher's Version](https://doi.org/10.1021/acssuschemeng.4c07508) ### 2024 van den Berg D, Asker D, Kim J, Kim H-Y, Aizenberg J, Hatton B. [Tuning the Topography of Non-Wetting Surfaces to Reduce Short-Term Microbial Contamination Within Hospitals](/publication/tuning-topography-non-wetting-surfaces-reduce-short-term-microbial-contamination-within). Advanced Functional Materials. 2024;34(32):2315957+. doi:https://doi.org/10.1002/adfm.202315957 van den Berg D, Asker D, Kim J, Kim H-Y, Aizenberg J, Hatton B. [Tuning the Topography of Non-Wetting Surfaces to Reduce Short-Term Microbial Contamination Within Hospitals](/publication/tuning-topography-non-wetting-surfaces-reduce-short-term-microbial-contamination-within). Advanced Functional Materials. 2024;34(32):2315957+. doi:https://doi.org/10.1002/adfm.202315957 - add\_circle\_outline do\_not\_disturb\_on Abstract Abstract Microbial contamination of hospital surfaces is a major contributor to infectious disease transmission. This work demonstrates that superhydrophobic (Cassie-Baxter) micro post topographies can significantly reduce cell attachment compared to flat... ### 2023 Frost IM, Mendoza AM, Chiou T-T, Kim P, Aizenberg J, Kohn DB, De Oliveira SN, Weiss PS, Jonas SJ. [Fluorinated Silane-Modified Filtroporation Devices Enable Gene Knockout in Human Hematopoietic Stem and Progenitor Cells.](/publication/fluorinated-silane-modified-filtroporation-devices-enable-gene-knockout-human) ACS applied materials & interfaces. 2023;15(35):41299–41309. doi:10.1021/acsami.3c07045 Frost IM, Mendoza AM, Chiou T-T, Kim P, Aizenberg J, Kohn DB, De Oliveira SN, Weiss PS, Jonas SJ. [Fluorinated Silane-Modified Filtroporation Devices Enable Gene Knockout in Human Hematopoietic Stem and Progenitor Cells.](/publication/fluorinated-silane-modified-filtroporation-devices-enable-gene-knockout-human) ACS applied materials & interfaces. 2023;15(35):41299–41309. doi:10.1021/acsami.3c07045 - add\_circle\_outline do\_not\_disturb\_on Abstract Intracellular delivery technologies that are cost-effective, non-cytotoxic, efficient, and cargo-agnostic are needed to enable the manufacturing of cell-based therapies as well as gene manipulation for research applications. Current technologies capable... Patel H, Pavlichenko I, Grinthal A, Zhang CT, Alvarenga J, Kreder MJ, Weaver JC, Ji Q, Ling CWF, Choy J, et al. [Design of medical tympanostomy conduits with selective fluid transport properties.](/publication/design-medical-tympanostomy-conduits-selective-fluid-transport-properties) Science translational medicine. 2023;15(690):eadd9779. doi:10.1126/scitranslmed.add9779 Patel H, Pavlichenko I, Grinthal A, Zhang CT, Alvarenga J, Kreder MJ, Weaver JC, Ji Q, Ling CWF, Choy J, et al. [Design of medical tympanostomy conduits with selective fluid transport properties.](/publication/design-medical-tympanostomy-conduits-selective-fluid-transport-properties) Science translational medicine. 2023;15(690):eadd9779. doi:10.1126/scitranslmed.add9779 - add\_circle\_outline do\_not\_disturb\_on Abstract Implantable tubes, shunts, and other medical conduits are crucial for treating a wide range of conditions from ears and eyes to brain and liver but often impose serious risks of device infection, obstruction, migration, unreliable function, and tissue... ### 2022 Kolle S, Ahanotu O, Meeks A, Stafslien S, Kreder M, Vanderwal L, Cohen L, Waltz G, Lim CS, Slocum D, et al. [On the mechanism of marine fouling-prevention performance of oil-containing silicone elastomers.](/publication/mechanism-marine-fouling-prevention-performance-oil-containing-silicone-elastomers) Scientific reports. 2022;12(1):11799. doi:10.1038/s41598-022-15553-4 Kolle S, Ahanotu O, Meeks A, Stafslien S, Kreder M, Vanderwal L, Cohen L, Waltz G, Lim CS, Slocum D, et al. [On the mechanism of marine fouling-prevention performance of oil-containing silicone elastomers.](/publication/mechanism-marine-fouling-prevention-performance-oil-containing-silicone-elastomers) Scientific reports. 2022;12(1):11799. doi:10.1038/s41598-022-15553-4 - add\_circle\_outline do\_not\_disturb\_on Abstract For many decades, silicone elastomers with oil incorporated have served as fouling-release coating for marine applications. In a comprehensive study involving a series of laboratory-based marine fouling assays and extensive global field studies of up to 2... Volkov V V, McMaster J, Aizenberg J, Perry C. [Mapping blood biochemistry by Raman spectroscopy at the cellular level ](/publications/mapping-blood-biochemistry-raman-spectroscopy-cellular-level). Chemical science. 2022;13(1):133–140. doi:10.1039/d1sc05764b Volkov V V, McMaster J, Aizenberg J, Perry C. [Mapping blood biochemistry by Raman spectroscopy at the cellular level ](/publications/mapping-blood-biochemistry-raman-spectroscopy-cellular-level). Chemical science. 2022;13(1):133–140. doi:10.1039/d1sc05764b - add\_circle\_outline do\_not\_disturb\_on Abstract We report how Raman difference imaging provides insight on cellular biochemistry *in vivo* as a function of sub-cellular dimensions and the cellular environment. We show that this approach offers a sensitive diagnostic to address blood biochemistry at the... ### 2017 Chen, Howell, Haller C, Patel M, Ayala, Moravec K, Dai, Liu, Sotiri, Aizenberg, et al. [An immobilized liquid interface prevents device associated bacterial infection in vivo](/publications/immobilized-liquid-interface-prevents-device-associated-bacterial-infection). Biomaterials. 2017;113:80–92. Chen, Howell, Haller C, Patel M, Ayala, Moravec K, Dai, Liu, Sotiri, Aizenberg, et al. [An immobilized liquid interface prevents device associated bacterial infection in vivo](/publications/immobilized-liquid-interface-prevents-device-associated-bacterial-infection). Biomaterials. 2017;113:80–92. - add\_circle\_outline do\_not\_disturb\_on Abstract Virtually all biomaterials are susceptible to biofilm formation and, as a consequence, device-associated infection. The concept of an immobilized liquid surface, termed *slippery liquid-infused porous surfaces* (SLIPS), represents a new framework for... Kovalenko, Sotiri, Timonen J, Overton J, Homes, Aizenberg, Howell. [Bacterial Interactions with Immobilized Liquid Layer](/publications/bacterial-interactions-immobilized-liquid-layer). Adv. Healthcare Mater. 2017;6(15):1600948. Kovalenko, Sotiri, Timonen J, Overton J, Homes, Aizenberg, Howell. [Bacterial Interactions with Immobilized Liquid Layer](/publications/bacterial-interactions-immobilized-liquid-layer). Adv. Healthcare Mater. 2017;6(15):1600948. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600948) Bacterial interactions with surfaces are at the heart of many infection-related problems in healthcare. In this work, the interactions of clinically relevant bacteria with immobilized liquid (IL) layers on oil-infused polymers are investigated. Although... - [ descriptionPublisher's Version](https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600948) Sutton, Shirman, Timonen J, England G, Kim, Kolle, Ferrante, Zarzar L, Strong, Aizenberg. [Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation](/publications/photothermally-triggered-actuation-hybrid-materials-new-platform-vitro-cell). Nat. Commun. 2017;8:14700. Sutton, Shirman, Timonen J, England G, Kim, Kolle, Ferrante, Zarzar L, Strong, Aizenberg. [Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation](/publications/photothermally-triggered-actuation-hybrid-materials-new-platform-vitro-cell). Nat. Commun. 2017;8:14700. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](http://nrs.harvard.edu/urn-3:HUL.InstRepos:32094141) Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical... - [ descriptionPublisher's Version](http://nrs.harvard.edu/urn-3:HUL.InstRepos:32094141) Alvarez M, Aizenberg, Analoui, Andrews A, Bisker, Boyden E, Kamm R, Karp J, Mooney D, Oklu, et al. [Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation](/publications/emerging-trends-micro-and-nanoscale-technologies-medicine-basic-discoveries). ACS Nano. 2017;11(6):5195–5214. Alvarez M, Aizenberg, Analoui, Andrews A, Bisker, Boyden E, Kamm R, Karp J, Mooney D, Oklu, et al. [Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation](/publications/emerging-trends-micro-and-nanoscale-technologies-medicine-basic-discoveries). ACS Nano. 2017;11(6):5195–5214. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://pubs.acs.org/doi/abs/10.1021/acsnano.7b01493) We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care... - [ descriptionPublisher's Version](https://pubs.acs.org/doi/abs/10.1021/acsnano.7b01493) Amini S, Kolle S, Petrone L, Ahanotu O, Sunny S, Sutanto C, Hoon S, Cohen L, Weaver JC, Aizenberg J, et al. [Preventing mussel adhesion using lubricant-infused materials](/publications/preventing-mussel-adhesion-using-lubricant-infused-materials). Science. 2017;357(6352):668–673. Amini S, Kolle S, Petrone L, Ahanotu O, Sunny S, Sutanto C, Hoon S, Cohen L, Weaver JC, Aizenberg J, et al. [Preventing mussel adhesion using lubricant-infused materials](/publications/preventing-mussel-adhesion-using-lubricant-infused-materials). Science. 2017;357(6352):668–673. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](http://science.sciencemag.org/cgi/content/full/357/6352/668?ijkey=uFJi2l9MM5Mxs&keytype=ref&siteid=sci) Mussels are opportunistic macrofouling organisms that can attach to most immersed solid surfaces, leading to serious economic and ecological consequences for the maritime and aquaculture industries. We demonstrate that lubricant-infused coatings exhibit... - [ descriptionPublisher's Version](http://science.sciencemag.org/cgi/content/full/357/6352/668?ijkey=uFJi2l9MM5Mxs&keytype=ref&siteid=sci) ### 2016 Sunny S, Cheng G, Daniel D, Lo P, Ochoa S, Howell C, Vogel N, Majid A, Aizenberg J. [Transparent antifouling material for improved operative field visibility in endoscopy](/publications/transparent-antifouling-material-improved-operative-field-visibility). Proc. Nat. Acad. Sci. 2016;113(42):11676–11681. Sunny S, Cheng G, Daniel D, Lo P, Ochoa S, Howell C, Vogel N, Majid A, Aizenberg J. [Transparent antifouling material for improved operative field visibility in endoscopy](/publications/transparent-antifouling-material-improved-operative-field-visibility). Proc. Nat. Acad. Sci. 2016;113(42):11676–11681. - add\_circle\_outline do\_not\_disturb\_on Abstract Inspection devices are frequently occluded by highly contaminating fluids that disrupt the visual field and their effective operation. These issues are particularly striking in endoscopes, where the diagnosis and treatment of diseases are compromised by... Juthani, Howell, Ledoux, Sotiri, Kelso, Kovalenko, Tajik, Vu T, Lin J, Sutton, et al. [Infused polymers for cell sheet release](/publications/infused-polymers-cell-sheet-release). Scientific Reports. 2016;6(1):26109. Juthani, Howell, Ledoux, Sotiri, Kelso, Kovalenko, Tajik, Vu T, Lin J, Sutton, et al. [Infused polymers for cell sheet release](/publications/infused-polymers-cell-sheet-release). Scientific Reports. 2016;6(1):26109. - add\_circle\_outline do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662258) Tissue engineering using whole, intact cell sheets has shown promise in many cell-based therapies. However, current systems for the growth and release of these sheets can be expensive to purchase or difficult to fabricate, hindering their widespread use... - [ descriptionPublisher's Version](http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662258) Hu Y, You, Aizenberg. [Micropatterned Hydrogel Surface with High-Aspect-Ratio Features for Cell Guidance and Tissue Growth](/publications/micropatterned-hydrogel-surface-high-aspect-ratio-features-cell-guidance-and). ACS Appl. Mater. Interfaces. 2016;8(34):21939–21945. Hu Y, You, Aizenberg. [Micropatterned Hydrogel Surface with High-Aspect-Ratio Features for Cell Guidance and Tissue Growth](/publications/micropatterned-hydrogel-surface-high-aspect-ratio-features-cell-guidance-and). ACS Appl. Mater. Interfaces. 2016;8(34):21939–21945. - add\_circle\_outline do\_not\_disturb\_on Abstract Surface topography has been introduced as a new tool to coordinate cell selection, growth, morphology, and differentiation. The materials explored so far for making such structural surfaces are mostly rigid and impermeable. Hydrogel, on the other hand, was... ### 2015 MacCallum N, Howell C, Kim P, Sun D, Friedlander R, Ranisau J, Ahanotu O, Lin J, Vena A, Hatton B, et al. [Liquid-Infused Silicone As a Biofouling-Free Medical Material](/publications/liquid-infused-silicone-biofouling-free-medical-material). ACS Biomater. Sci. Eng. 2015;1(1):43–51. doi:10.1021/ab5000578 MacCallum N, Howell C, Kim P, Sun D, Friedlander R, Ranisau J, Ahanotu O, Lin J, Vena A, Hatton B, et al. [Liquid-Infused Silicone As a Biofouling-Free Medical Material](/publications/liquid-infused-silicone-biofouling-free-medical-material). ACS Biomater. Sci. Eng. 2015;1(1):43–51. doi:10.1021/ab5000578 - add\_circle\_outline do\_not\_disturb\_on Abstract There is a dire need for infection prevention strategies that do not require the use of antibiotics, which exacerbate the rise of multi- and pan-drug resistant infectious organisms. An important target in this area is the bacterial attachment and... - Previous page chevron\_left - [1](?page=0%2C0 "Current page") - [2](?page=1%2C0 "Go to page 2") - [ Next page chevron\_right ](?page=1%2C0 "Go to next page") ## In the News [Clinging to crevices, E. coli thrive](http://www.seas.harvard.edu/news/2013/04/clinging-crevices-e-coli-thrive), Harvard press release, April 10, 2013.