#  Laser-Induced Cell Delivery 

 



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#### Laser-Induced Cell Delivery

T cells play a central role in the adaptive immune system by recognizing and responding to specific antigens with remarkable precision. Their role in combating infections and in regulating immune responses has positioned them as a focal point in the development of cell based therapeutics, and the success of T cell-based therapies has spurred a growing number of clinical trials. Adoptive T cell therapy involves the infusion of patient specific activated, tumor-specific T cells. This type of therapy has shown the ability to induce complete and durable regression in certain advanced cancers. Despite the clinical success of T cell therapy and associated advances in research, challenges for widely available personalized medicine persist. Efficient and scalable delivery of nucleic acids to T cells for genetic engineering of these cells remains a significant bottleneck due to challenges associated with viral vectors including high production cost, limited scalability, genotoxicity and limited cargo capacity. In collaboration with the Mazur lab, we use a near infrared laser irradiation of structured materials to porate the cell membrane and deliver otherwise impermeable biomolecules.

   ![Cell therapy schematic](/sites/g/files/omnuum6296/files/styles/hwp_1_1__720x720_scale/public/2025-02/Fig_1.png?itok=lh5yGap1) 

 

**Contact:** Reena Paink