Khan, Mughees

Hou X, Hu Y, Grinthal A, Khan M, Aizenberg J. Liquid-based gating mechanism with tunable multiphase selectivity and antifouling behaviour. Nature. 2015;519 (7541) :70-73. Full TextAbstract
Living organisms make extensive use of micro- and nanometre-sized pores as gatekeepers for controlling the movement of fluids, vapours and solids between complex environments. The ability of such pores to coordinate multiphase transport, in a highly selective and subtly triggered fashion and without clogging, has inspired interest in synthetic gated pores for applications ranging from fluid processing to 3D printing and lab-on-chip systems. But although specific gating and transport behaviours have been realized by precisely tailoring pore surface chemistries and pore geometries, a single system capable of controlling complex, selective multiphase transport has remained a distant prospect, and fouling is nearly inevitable. Here we introduce a gating mechanism that uses a capillary-stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state. Theoretical modelling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables us to realize in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow us to dynamically modulate gas–liquid sorting in a microfluidic flow and to separate a three-phase air–water–oil mixture, with the liquid lining ensuring sustained antifouling behaviour. Because the liquid gating strategy enables efficient long-term operation and can be applied to a variety of pore structures and membrane materials, and to micro- as well as macroscale fluid systems, we expect it to prove useful in a wide range of applications.
England G, Kolle M, Kim P, Khan M, Munoz P, Mazur E, Aizenberg J. Bioinspired micrograting arrays mimicking the reverse color diffraction elements evolved by the butterfly Pierella luna. Proc. Nat. Acad. Sci. 2014;111 (44) :15630–15634. Full TextAbstract

Recently, diffraction elements that reverse the color sequence normally observed in planar diffraction gratings have been found in the wing scales of the butterfly Pierella luna. Here, we describe the creation of an artificial photonic material mimicking this re- verse color-order diffraction effect. The bioinspired system con- sists of ordered arrays of vertically oriented microdiffraction gratings. We present a detailed analysis and modeling of the cou- pling of diffraction resulting from individual structural compo- nents and demonstrate its strong dependence on the orientation of the individual miniature gratings. This photonic material could provide a basis for novel developments in biosensing, anticoun- terfeiting, and efficient light management in photovoltaic systems and light-emitting diodes.

Friedlander RS, Vlamakis H, Kim P, Khan M, Kolter R, Aizenberg J. Bacterial flagella explore microscale hummocks and hollows to increase adhesion. Proc. Nat. Acad. Sci. 2013;110 (14) :5624-5629. Publisher's VersionAbstract
Biofilms, surface-bound communities of microbes, are economically and medically important due to their pathogenic and obstructive properties. Among the numerous strategies to prevent bacterial adhesion and subsequent biofilm formation, surface topography was recently proposed as a highly nonspecific method that does not rely on small-molecule antibacterial compounds, which promote resistance. Here, we provide a detailed investigation of how the introduction of submicrometer crevices to a surface affects attachment of Escherichia coli. These crevices reduce substrate surface area available to the cell body but increase overall surface area. We have found that, during the first 2 h, adhesion to topographic surfaces is significantly reduced compared with flat controls, but this behavior abruptly reverses to significantly increased adhesion at longer exposures. We show that this reversal coincides with bacterially induced wetting transitions and that flagellar filaments aid in adhesion to these wetted topographic surfaces. We demonstrate that flagella are able to reach into crevices, access additional surface area, and produce a dense, fibrous network. Mutants lacking flagella show comparatively reduced adhesion. By varying substrate crevice sizes, we determine the conditions under which having flagella is most advantageous for adhesion. These findings strongly indicate that, in addition to their role in swimming motility, flagella are involved in attachment and can furthermore act as structural elements, enabling bacteria to overcome unfavorable surface topographies. This work contributes insights for the future design of antifouling surfaces and for improved understanding of bacterial behavior in native, structured environments.
Kang SH, Shan S, Noorduin WL, Khan M, Aizenberg J, Bertoldi K. Buckling-Induced Reversible Symmetry Breaking and Amplification of Chirality Using Supported Cellular Structures. Adv. Mater. 2013;25 (24) :3380-3385. Publisher's Version
Kim P, Adorno-Martinez WE, Khan M, and Aizenberg J. Enriching libraries of high-aspect-ratio micro- or nanostructures by rapid, low-cost, benchtop nanofabrication. Nature Protocols. 2012;7 (2) :311–327. 2012_Kim_natprot.pdf
Grinthal A, Kang SH, Epstein AK, Aizenberg M, Khan M, Aizenberg J. Steering nanofibers: An integrative approach to bio-inspired fiber fabrication and assembly. Nano Today. 2012;7 (1) :35-52. 2012_NanoToday_review.pdf
Kim P, Epstein AK, Khan M, Zarzar LD, Lipomi DJ, Whitesides GM, and Aizenberg J. Structural Transformation by Electrodeposition on Patterned Substrates (STEPS) - A New Versatile Nanofabrication Method. Nano Lett. 2012;12 (2) :527-533. 2011_NanoLett_Phil.pdf